There are many problems in the development process of the low permeability oilfields including water injection difficulty, high water flooded degree, low utilization efficiency of injected water and gas channeling of gas injection. Through a large number of laboratory physical simulation experiments and tests, the best CO2foam system was selected out for a low permeability blocks CO2foam flooding in Jilin oil field. The stability, foaminess, injectivity and applicable scope of the permeability of three systems were conducted. The results showed that the three kinds of foam agent all had good foaminess and stability, and all of them could be injected within the range. When the temperature rose from 45 ℃ to 100 ℃, the halflife of foam systems sharply reduced, and the stability of them turned bad. In the three foam systems, FP388 was the optimal one which had best foaminess and comprehensive performance.